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HMGB1-facilitated p53 DNA binding occurs via HMG-Box/p53 transactivation domain interaction, regulated by the acidic tail

Specifically, it increases the F/B ratio and decreases the abundance of Clostridia, Melainabacteria, Lachnospiracea e, Desulfovibrionaceae , Lachnospiraceae_NK4A136_group, Ruminococcaceae_UCG-005, Faecalibacterium, Desulfovibrio, Anaerotruncus, Lachnospiraceae_UCG-001 and Erysipelatoclostridium while increasing the abundance of Alloprevotella, Prevotellaceae_UCG-003, Clostridium_sensu_stricto_1, Lactobacillus, Bifidobacterium , Prevotellaceae_NK3B31_group, Akkermansia and Ruminococcus

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Gastrointestinal discomfort (e.g., nausea, bloating, cramping)

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